9-Phenanthrol

9-Phenanthrol is an inhibitor of transient receptor potential melastatin 4 (TRPM4, IC50s = 19.1, 17.1, and 22.8 µM at +40, -40, and -80 mV, respectively, in HEK293 cells expressing the human receptor). It is selective for TRPM4 over TRPM5 at 100 µM. 9-Phenanthrol (100 µM) reduces heart rate in spontaneously beating isolated mouse right atria. It reduces infarct size and apoptosis in isolated rat hearts in an ex vivo model of ischemia-reperfusion injury. In vivo, 9-phenanthrol reduces myogenic tone in rat cerebral arteries.CAS Number: 484-17-3. Synonyms: 9-Hydroxyphenanthrene, NSC 50554. Molecular Formula: C14H10O. Formula Weight: 194.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: :, DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 249, 254 nm. SMILES: OC1=CC2=C(C3=C1C=CC=C3)C=CC=C2. InChi Code: InChI=1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H. InChi Key: DZKIUEHLEXLYKM-UHFFFAOYSA-N.