9-hydroxy Stearic Acid

Description: 9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (5 µM) was stearic acid, which inhibited the expression of histone deacetylase 1 (HDAC1) in the lysate of HT-29 colon cancer cells. 3. When the concentration was 100 µM.1, the proliferation of HT-29 cells was inhibited and cell cycle arrest was induced in G0/ g1 phase. Target: HDAC. Smiles: C(C(CCCCCCCCC)O)CCCCCCC(O)=O. References: Calonghi N, et al. 9-Hydroxystearic acid upregulates p21(WAF1) in HT29 cancer cells. Biochem Biophys Res Commun. 2004,314(1):138-14