8-Bromoguanosine

8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the syn conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function. It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.Formal Name: 8-bromo-guanosine. CAS Number: 4016-63-1. Synonyms: 2-Amino-8-bromo-6-hydroxypurine riboside, NSC 79211, NSC 174257. Molecular Formula: C10H12BrN5O5. Formula Weight: 362.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml. lambdamax: 261 nm. SMILES: O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C(Br)=N2)N=C(N)N1. InChi Code: InChI=1S/C10H12BrN5O5/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20)/t2-,4-,5-,8-/m1/s1. InChi Key: ASUCSHXLTWZYBA-UMMCILCDSA-N.