8,11,14-Eicosatriynoic Acid

8,11,14-Eicosatriynoic acid is an inhibitor of prostaglandin and leukotriene biosynthesis as well as arachidonic acid induced platelet aggregation. It inhibits cyclooxygenase (IC50 = 14 µM), human 12-lipoxygenase (IC50 = 0.46 µM), 5-lipoxygenase (IC50 = 25 µM) and the actions of slow-reacting substance of anaphylaxis (SRS-A) (IC50 = 10 µM).Formal Name: 8,11,14-eicosatriynoic acid. CAS Number: 34262-64-1. Synonyms: 8,11,14-ETI, FA 20:6. Molecular Formula: C20H28O2. Formula Weight: 300.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.15 M Tris-HCl (pH 8.5): 1 mg/ml, DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 0.15 mg/ml. SMILES: CCCCCC#CCC#CCC#CCCCCCCC(O)=O. InChi Code: InChI=1S/C20H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-5,8,11,14-19H2,1H3,(H,21,22). InChi Key: QLLIWTBTVOPGCM-UHFFFAOYSA-N.