7-Nitroindazole

7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 µM, respectively.Formal Name: 7-nitro-1H-indazole. CAS Number: 2942-42-9. Molecular Formula: C7H5N3O2. Formula Weight: 163.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetone: 10 mg/ml, DMF: >54 mg/ml, DMSO: >100 mg/ml, DMSO:10 mM Na2CO3 (10:90): 1 mg/ml, Ethanol: 2.68 mg/ml, Ethyl Acetate: 10 mg/ml, PBS pH 7.2: <50 µg/ml. lambdamax: 228, 300, 357 nm. SMILES: [H]N1C2=C([N+]([O-])=O)C=CC=C2C=N1. InChi Code: InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9). InChi Key: PQCAUHUKTBHUSA-UHFFFAOYSA-N.