7,8-Dihydroneopterin

7,8-Dihydroneopterin is a pteridine with antioxidant activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in a cell-free assay when used at concentrations ranging from 20 to 100 µM. 7,8-Dihydroneopterin (2-10 µM) inhibits copper ion-induced oxidation of LDL in a cell-free assay and decreases thiobarbituric acid reactive substances (TBARS) produced by THP-1 cells cultured with LDL. It inhibits necrosis induced by oxidized LDL (oxLDL) in U937, but not THP-1, cells when used at a concentration of 200 µM.Formal Name: 2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone. CAS Number: 1218-98-0. Synonyms: D-erythro-7,8-Dihydroneopterin. Molecular Formula: C9H13N5O4. Formula Weight: 255.2. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.3 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 217, 235, 275, 346 nm. SMILES: O=C1C2=C(NCC([C@H](O)[C@H](O)CO)=N2)NC(N)=N1. InChi Code: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1. InChi Key: YQIFAMYNGGOTFB-XINAWCOVSA-N.