6PPD-Q

Description: 6PPD-Q (6PPD-Quinone) is an environmental pollutant that can target CNR2, CNR1, AA2AR, LCAT and TRPA1. Among them, CNR2 has the highest binding affinity and may act as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q can damage the sperm quality and induce the impairment of male reproductive ability in mice. 6PPD-Q can induce intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolytic metabolites and TCA cycle intermediates, and exacerbating alpha-synuclein (alpha-syn) aggregation. Target: Endogenous Metabolite. Smiles: O=C1C=C(NC(C)CC(C)C)C(=O)C=C1NC=2C=CC=CC2. References: Fang J, et al. 6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by alpha-synuclein preformed fibrils seeding. J Hazard Mater. 2024 Mar 5,465:133312.