6-Methylsulfinylhexyl isothiocyanate

6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities. It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM. It inhibits aggregation of isolated human platelets induced by arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607, IC50 = 21.9 µM). 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM). In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson's disease induced by 6-OHDA (Cay-25330). 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.Formal Name: 1-isothiocyanato-6-(methylsulfinyl)-hexane. CAS Number: 4430-35-7. Synonyms: 6-MSITC. Molecular Formula: C8H15NOS2. Formula Weight: 205.3. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/mL, DMSO: 30mg/mL, Ethanol: 50 mg/mL, PBS (pH 7.2): 10 mg/mL. SMILES: S=C=NCCCCCCS(C)=O. InChi Code: InChI=1S/C8H15NOS2/c1-12(10)7-5-3-2-4-6-9-8-11/h2-7H2,1H3. InChi Key: XQZVZULJKVALRI-UHFFFAOYSA-N.