6-Mercaptopurine (hydrate)

6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion. It is rapidly converted to 6-mercaptopurine ribonucleoside-5'-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limiting enzyme in purine synthesis. It also inhibits the conversion of IMP to adenylosuccinic acid and xanthylic acid and blocks AMP formation in vitro. 6-MP (30 mg/kg) inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice. It also decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset. Formulations containing mercaptopurine have been used for maintenance therapy in patients with acute lymphoblastic leukemia.Formal Name: 1,2,3,9-tetrahydro-6H-purine-6-thione, monohydrate. CAS Number: 6112-76-1. Synonyms: 6-MP. Molecular Formula: C5H4N4S . H2O. Formula Weight: 170.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 202, 330 nm. SMILES: S=C1C2=C(NC=N2)N=CN1.O. InChi Code: InChI=1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5,/h1-2H,(H2,6,7,8,9,10),1H2. InChi Key: WFFQYWAAEWLHJC-UHFFFAOYSA-N.