5'-pApA (sodium salt)

5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).{24607, 50984,61373,61374} It is a metabolite of cyclic di-AMP (Cay-17753) formed via hydrolysis by various phosphodiesterases (PDEs). 5'-pApA is intended for use as a negative control for cyclic di-AMP signaling.Formal Name: 5'-O-phosphonoadenylyl-(3'->5')-adenosine, trisodium salt. Synonyms: c-di-AMP Control, Cyclic di-AMP Negative Control. Molecular Formula: C20H23N10O13P2 . 3Na. Formula Weight: 742.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: O=P(O[C@H]1[C@@H](O)[C@@](N2C3=NC=NC(N)=C3N=C2)([H])O[C@@H]1COP([O-])([O-])=O)([O-])OC[C@@H]4[C@@H](O)[C@@H](O)[C@@](N5C6=NC=NC(N)=C6N=C5)([H])O4.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C20H26N10O13P2.3Na/c21-15-9-17(25-3-23-15)29(5-27-9)19-12(32)11(31)7(41-19)1-40-45(37,38)43-14-8(2-39-44(34,35)36)42-20(13(14)33)30-6-28-10-16(22)24-4-26-18(10)30,,,/h3-8,11-14,19-20,31-33H,1-2H2,(H,37,38)(H2,21,23,25)(H2,22,24,26)(H2,34,35,36),,,/q,3*+1/p-3/t7-,8-,11-,12-,13-,14-,19-,20-,,,/m1.../s1. InChi Key: FZHMLQPWUIQMMB-JJCYRVQFSA-K. Origin: Synthetic.