4-Methylumbelliferyl beta-D-Galactopyranoside-6-sulfate (sodium salt)

4-Methylumbelliferyl beta-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity. 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient. 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.Formal Name: 4-methyl-7-[(6-O-sulfo-beta-D-galactopyranosyl)oxy]-2H-1-benzopyran-2-one, monosodium salt. CAS Number: 206443-06-3. Synonyms: 4-MU beta-D-galactopyranoside-6-sulfate, 4-Methylumbelliferyl Gal-6S, 4-MU-Gal-6S. Molecular Formula: C16H17O11S . Na. Formula Weight: 440.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 318 nm. SMILES: O=C(O1)C=C(C)C(C1=C2)=CC=C2O[C@@H]3O[C@H](COS([O-])(=O)=O)[C@H](O)[C@H](O)[C@H]3O.[Na+]. InChi Code: InChI=1S/C16H18O11S.Na/c1-7-4-12(17)26-10-5-8(2-3-9(7)10)25-16-15(20)14(19)13(18)11(27-16)6-24-28(21,22)23,/h2-5,11,13-16,18-20H,6H2,1H3,(H,21,22,23),/q,+1/p-1/t11-,13+,14+,15-,16-,/m1./s1. InChi Key: KHTOBGQRIASILC-XNSOHGFJSA-M.