4-epi Minocycline

4-epi Minocycline is the main degradation product of and a potential impurity in commercial preparations of minocycline. Minocycline (Cay-14454) is a broad spectrum tetracycline antibiotic that has a particularly long half-life in serum. Formulations containing minocycline have been used in the treatment of acne in older patients. Minocycline also has both anti-inflammatory and neuroprotective actions.Formal Name: (4R,4aS,5aR,12aS)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide. CAS Number: 43168-51-0. Synonyms: 4-EMC, Minocycline Impurity A. Molecular Formula: C23H27N3O7. Formula Weight: 457.5. Purity: >80%. Formulation: (Request formulation change), A solid. Solubility: Aqueous acid: soluble. SMILES: NC(C1=C(O)[C@H](N(C)C)[C@@]2([H])[C@](C1=O)(O)C(O)=C3C(C4=C(O)C=CC(N(C)C)=C4C[C@@]3([H])C2)=O)=O. InChi Code: InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17+,23-/m0/s1. InChi Key: DYKFCLLONBREIL-MJPDVNATSA-N.