4-Desmethoxy Omeprazole

Description: 4-Desmethoxy Omeprazole, the active metabolite of Omeprazole, acts as a proton pump inhibitor (PPI) and demonstrates competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 µM. Target: Drug Metabolite. Smiles: COc1ccc2[nH]c(nc2c1)S(=O)Cc1ncc(C)cc1C. References: Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug,32(8):821-7.