4-(2,2,3-Trimethylcyclopentyl)butanoic Acid

4-(2,2,3-Trimethylcyclopentyl)butanoic acid is an orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43. It prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells with IC50 values of 7.9 and 2.4 µM, respectively. In human sensory trials, 4-(2,2,3-trimethylcyclopentyl)butanoic acid significantly reduced the bitter flavor associated with these two artificial sweeteners.Formal Name: 2,2,3-trimethyl-cyclopentanebutanoic acid. CAS Number: 957136-80-0. Synonyms: GIV3727. Molecular Formula: C12H22O2. Formula Weight: 198.3. Purity: >98%. Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 0.25 mg/ml. SMILES: OC(CCCC1CCC(C)C1(C)C)=O. InChi Code: InChI=1S/C12H22O2/c1-9-7-8-10(12(9,2)3)5-4-6-11(13)14/h9-10H,4-8H2,1-3H3,(H,13,14). InChi Key: LYFXCRCUENNESS-UHFFFAOYSA-N.