3-Nitropropionic Acid

3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain. This compound is a natural toxin of certain plants and fungi. Administration of 3-NP to rats (12 mg/kg per day) produces progressive striatal degeneration, while lower doses (8 mg/kg daily) in nonhuman primates results in neuropathologic and clinical features of Huntington's disease. Conversely, Huntington's disease results in a loss of Complex II activity. 3-NP also induces convulsions and is used to examine interventions effective in a mouse model of epilepsy.Formal Name: 3-nitro-propanoic acid. CAS Number: 504-88-1. Synonyms: beta-Nitropropionic Acid, 3-NP, NSC 64266. Molecular Formula: C3H5NO4. Formula Weight: 119.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, Ethanol: 10 mg/ml. SMILES: OC(CC[N+]([O-])=O)=O. InChi Code: InChI=1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6). InChi Key: WBLZUCOIBUDNBV-UHFFFAOYSA-N.