3-Bromotyrosine-13C9,15N (trifluoroacetate salt)

3-Bromotyrosine-13C9,15N is intended for use as an internal standard for the quantification of 3-bromotyrosine (Cay-22606) by GC- or LC-MS. 3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response. It has been used as a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo. In addition to its production in eosinophils, 3-bromotyrosine is found at 5-fold higher levels in peritoneal exudate from mice infected with K. pneumoniae compared with uninfected animals, suggesting neutrophils release higher levels of oxidized products during inflammation. In a human study, 3-bromotyrosine was increased in allergen-challenged lung samples from subjects with allergen-induced asthma.Formal Name: (S)-2-(amino-15N)-3-(3-bromo-4-hydroxyphenyl-1,2,3,4,5,6-13C6)propanoic-1,2,3-13C3 acid, 2,2,2-trifluoroacetic acid. Synonyms: 3-bromo-Tyr-13C9,15N. Molecular Formula: [13C9]H10Br[15N]O3 . CF3COOH. Formula Weight: 384.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL, PBS (pH 7.2): 10 mg/mL. SMILES: Br[13C]1=[13C](O)[13CH]=[13CH][13C]([13CH2][13C@H]([15NH2])[13C](O)=O)=[13CH]1.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C9H10BrNO3.C2HF3O2/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14,3-2(4,5)1(6)7/h1-3,7,12H,4,11H2,(H,13,14),(H,6,7)/t7-,/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,11+1,. InChi Key: ZTELCZMTUMDSGB-HLRMJPPESA-N.