3-bromo-5-phenyl Salicylic Acid

The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20alpha-HSD and the other three being 3alpha-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20alpha-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 µM), and AKR1C4 (Ki = 18.2 µM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).Formal Name: 5-bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid. CAS Number: 4906-68-7. Synonyms: NSC 109116. Molecular Formula: C13H9BrO3. Formula Weight: 293.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 12.5 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 233, 326 nm. SMILES: BrC1=CC(C2=CC=CC=C2)=CC(C(O)=O)=C1O. InChi Code: InChI=1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17). InChi Key: XVZSXNULHSIRCQ-UHFFFAOYSA-N.