20(S)-Protopanaxadiol

20(S)-Protopanaxadiol is a sapogenin and an isomer of 20(R)-protopanaxadiol (Cay-25052) that has been found in P. ginseng and has anticancer and antibacterial activities. 20(S)-Protopanaxadiol is cytotoxic to MT-4 human T cell leukemia cells with a 50% cytotoxic concentration (CC50) value of 7.2 µM and inhibits the growth of human A549 lung carcinoma, SKOV3 ovarian adenocarcinoma, SK-MEL-2 melanoma, and K562 chronic leukemia cells (EC50s = 9.8-20 µM), as well as P388 and L1210 murine leukemia cells (EC50s = 9.8 and 10 µM, respectively). It also inhibits the growth of H. pylori in vitro (MIC = 50 µg/ml).Formal Name: dammar-24-ene-3beta,12beta,20-triol. CAS Number: 30636-90-9. Synonyms: 20(S)-APPD, 20-Epiprotopanaxadiol. Molecular Formula: C30H52O3. Formula Weight: 460.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, Ethanol: 5 mg/ml. SMILES: C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)O)([H])[C@]([C@@](CC/C=C(C)/C)(C)O)([H])CC3)C. InChi Code: InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1. InChi Key: PYXFVCFISTUSOO-HKUCOEKDSA-N. Origin: Plant/Panax ginseng.