20-O-Acetylingenol-3-angelate

20-O-Acetylingenol-3-angelate is a diterpene ester that has been found in E. peplus and a derivative of ingenol-3-angelate (Cay-16207) that has anticancer activity. It inhibits the growth of K562, HL-60, KT-1, MCF-7/adr, A549, and NIH3T3 cells when used at a concentration of 12.5 µM. 20-O-Acetylingenol-3-angelate (31.25-500 nM) induces cell cycle arrest at the G2/M phase, apoptosis, and necrosis in K562 cells.Formal Name: (2Z)-2-methyl-2-butenoic acid, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-4-[(acetyloxy)methyl]-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester. CAS Number: 82425-35-2. Synonyms: AAI, 3-O-Angeloyl-20-O-acetyl Ingenol, PEP008. Molecular Formula: C27H36O7. Formula Weight: 472.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, Chloroform: Sparingly Soluble: 1-10 mg/ml. SMILES: O[C@@]12[C@]3(C=C([C@@H]2OC(/C(C)=C\C)=O)C)C([C@](C=C([C@H]1O)COC(C)=O)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]3C)=O. InChi Code: InChI=1S/C27H36O7/c1-8-13(2)24(31)34-23-14(3)11-26-15(4)9-19-20(25(19,6)7)18(22(26)30)10-17(12-33-16(5)28)21(29)27(23,26)32/h8,10-11,15,18-21,23,29,32H,9,12H2,1-7H3/b13-8-/t15-,18+,19-,20+,21-,23+,26+,27+/m1/s1. InChi Key: ZYCAGKYWXRKLSN-KLKWOBOISA-N. Origin: Plant/Euphorbia pekinensis Rupr..