2-Methylthioadenosine triphosphate (sodium salt)

2-Methylthioadenosine triphosphate is an agonist of the purinergic P2X2 and P2Y1 receptors. It is also an inhibitor of guanylate cyclase C (GC-C) in rat intestinal mucosal membranes (Ki = 360 µM in the presence of E. coli heat-stable enterotoxin). 2-Methylthioadenosine triphosphate (1 µM) induces calcium influx in primary rat arcuate nucleus neurons in a fluorescence-based reporter assay. It increases inositol phosphate accumulation in 1321N1 astrocytoma cells expressing human P2Y1 receptors (EC50 = 51 nM). 2-Methylthioadenosine triphosphate inhibits uroguanylin-induced increases in urine flow and sodium excretion in rats.Formal Name: 2-(methylthio)-adenosine 5'-(tetrahydrogen triphosphate), tetrasodium salt. CAS Number: 100020-57-3. Synonyms: 2-methylthio ATP, 2-MeSATP. Molecular Formula: C11H14N5O13P3S . 4Na. Formula Weight: 641.2. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: PBS (pH 7.2): 10 mg/ml, Water: Soluble. lambdamax: 234, 275 nm. SMILES: O[C@H]1[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C11H18N5O13P3S.4Na/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21,,,,/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21),,,,/q,4*+1/p-4/t4-,6-,7-,10-,,,,/m1..../s1. InChi Key: UEEFBRHXFDJPTA-KWIZKVQNSA-J.