2'-Deoxyinosine

2'-Deoxyinosine is the nucleoside form of hypoxanthine (Cay-22254). It is a product of DNA damage that is formed from 2'-deoxyadenosine (Cay-27315) by adenosine deaminase or reactive nitrogen species (RNS). 2'-deoxyinosine (1 mM) enhances apoptosis induced by 5-fluorouracil (5-FU, Cay-14416) in HT-29 and SW620 cancer cells. It also enhances 5-FU-induced tumor growth suppression in an SW620 mouse xenograft model when administered at a dose of 1.6 g/kg twice per day.CAS Number: 890-38-0. Molecular Formula: C10H12N4O4. Formula Weight: 252.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly soluble, DMSO: slightly soluble. lambdamax: 246 nm. SMILES: O=C1C2=C(NC=N1)N([C@]3([H])O[C@H](CO)[C@@H](O)C3)C=N2O=C1C2=C(NC=N1)N([C@]3([H])O[C@H](CO)[C@@H](O)C3)C=N2. InChi Code: InChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1. InChi Key: VGONTNSXDCQUGY-RRKCRQDMSA-N.