2'-Deoxycytidine-5'-monophosphate

2'-Deoxycytidine-5'-monophosphate (dCMP) is a deoxyribonucleotide. It is formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria. It is further phosphorylated by UMP-CMP kinase to form dCDP (Cay-22982) during nucleic acid synthesis. dCMP (700 mg/kg) decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams. Oral administration of dCMP in combination with dTMP increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.Formal Name: 2'-deoxy-5'-cytidylic acid. CAS Number: 1032-65-1. Synonyms: dCMP, Deoxycytidylate. Molecular Formula: C9H14N3O7P. Formula Weight: 307.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 0.3mg/mL. lambdamax: 277 nm. SMILES: OP(OC[C@@H]1[C@@H](O)C[C@]([H])(N2C=CC(N)=NC2=O)O1)(O)=O. InChi Code: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1. InChi Key: NCMVOABPESMRCP-SHYZEUOFSA-N.