2,5-Anhydro-D-mannitol

Description: 2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism. Target: Others. Smiles: OC[C@H]1O[C@H](CO)[C@@H](O)[C@@H]1O