2,3-DCPE (hydrochloride)

2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells. It induces apoptosis in vitro in various cancer cell lines (IC50s = 0.89-2.69 µM) more effectively than in normal human fibroblasts (IC50 = 12.6 µM). 2,3-DCPE down-regulates Bcl-xL, however forced overexpression of Bcl-xL is sufficient to block 2,3-DCPE apoptosis induction. 2,3-DCPE can induce S-phase arrest, upregulate p21, and activate ERK.Formal Name: 2-[[3-(2,3-dichlorophenoxy)propyl]amino]-ethanol, monohydrochloride. CAS Number: 1009555-55-8. Molecular Formula: C11H15Cl2NO2 . HCl. Formula Weight: 300.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: ClC1=C(Cl)C(OCCCN([H])CCO)=CC=C1.Cl. InChi Code: InChI=1S/C11H15Cl2NO2.ClH/c12-9-3-1-4-10(11(9)13)16-8-2-5-14-6-7-15,/h1,3-4,14-15H,2,5-8H2,1H. InChi Key: GFCJFYSIPRIHKT-UHFFFAOYSA-N.