2,3,5,6-Tetramethylpyrazine

2,3,5,6-Tetramethylpyrazine is an alkaloid that has been found in L. wallichii and has diverse biological activities. It reduces kainate-induced increases in production of reactive oxygen species (ROS) and cytotoxicity in primary rat hippocampal neurons when used at a concentration of 5 µM. 2,3,5,6-Tetramethylpyrazine (0.1 mM) induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats. It decreases infarct volume, caspase-3 activation, and hypoxia-inducible factor-1alpha (HIF-1alpha) levels in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 20 mg/kg.CAS Number: 1124-11-4. Synonyms: Chuanxingzine, NSC 36080, NSC 46451, Tetramethylpyrazine. Molecular Formula: C8H12N2. Formula Weight: 136.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml. SMILES: CC1=C(C)N=C(C)C(C)=N1. InChi Code: InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3. InChi Key: FINHMKGKINIASC-UHFFFAOYSA-N. Origin: Synthetic.