17alpha,20beta-Dihydroxy-4-pregnen-3-one

Description: 17alpha,20beta-Dihydroxy-4-pregnen-3-one (17alpha,20beta-DHP) is an endogenous, maturation-inducing steroid that stimulates oocyte maturation in female teleost species. For instance, 1 µg/ml of 17alpha,20beta-DHP induces germinal vesicle breakdown in Persian sturgeon oocytes, a key step in maturation. Gonadotropin-releasing hormone and gonadotropins (follicle-stimulating hormone and luteinizing hormone) stimulate the production of 17alpha,20beta-DHP in vivo or in vitro. 17alpha,20beta-DHP also influences spermiation by stimulating milt production at 5 mg/kg in various male teleosts. Target: Others. Smiles: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](C)O)O)[H]. References: Milla, S., Terrien, X., Sturm, A., et al. Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: Implication with 17alpha, 2betadihydroxyprogesterone on the milt fluidity? Reproductive Biology and Endocrinology 6, 19 (2008).