15(R)-Pinane Thromboxane A2

Description: 15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 µM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 µg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle. Target: Others. Smiles: [H][C@@]12C[C@@]([H])([C@H](C\C=C/CCCC(O)=O)[C@H](C1)\C=C\[C@H](O)CCCCC)C2(C)C , TLB:6:5:26:2,17:15:26:2,