14-deoxy-11,12-didehydro Andrographolide

14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide (Cay-11679) that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 µg/ml) that can occur with andrographolide 6.5 µg/ml.Formal Name: 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-2(5H)-furanone. CAS Number: 42895-58-9. Synonyms: 14-dehydro Andrographolide. Molecular Formula: C20H28O4. Formula Weight: 332.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 2 mg/ml. lambdamax: 247 nm. SMILES: C=C1CC[C@]2([H])[C@@](CO)(C)[C@H](O)CC[C@@]2(C)[C@@H]1/C=C/C3=CCOC3=O. InChi Code: InChI=1S/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5-6,9,15-17,21-22H,1,4,7-8,10-12H2,2-3H3/b6-5+/t15-,16+,17-,19+,20+/m1/s1. InChi Key: XMJAJFVLHDIEHF-CRBRZBHVSA-N. Origin: Plant/Andrographis paniculata.