1-EBIO

1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 µM in T84 human carcinoma cells). This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B. In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents. It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 µM). 1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.Formal Name: 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one. CAS Number: 10045-45-1. Synonyms: 1-Ethylbenzimidazolinone. Molecular Formula: C9H10N2O. Formula Weight: 162.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 30 mg/ml. lambdamax: 229, 285 nm. SMILES: O=C(N1CC)NC2=C1C=CC=C2. InChi Code: InChI=1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12). InChi Key: CXUCKELNYMZTRT-UHFFFAOYSA-N.