1-beta-D-Glucosylsphingadienine (d18:2 (4E,8E))

Description: 1-beta-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 µM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3), thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-beta-D-glucosylsphingadienine isolated from plants. Target: Others. Smiles: CCCCCCCCCC=CCCC=CC(O)C(N)COC1OC(CO)C(O)C(O)C1O , w:14.14,10.10,