1-beta-D-Glucosylsphingadienine

1-beta-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides (Cay-23206, Cay-23207). They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 µM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3), thus, glucosylsphingosine has been used as a key biomarker of the disease. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1310]Formal Name: 2S-amino-3R-hydroxy-4E,8E-octadecadienyl, beta-D-glucopyranoside. CAS Number: 114200-59-8. Synonyms: Glucosylsphingadienine (d18:2 (4E,8E)), 1-beta-D-Glucosylsphingadienine (plant), Glucosylsphingosine (plant). Molecular Formula: C24H45NO7. Formula Weight: 459.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol (4:1): Soluble. SMILES: O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]([C@H](O)/C=C/CC/C=C/CCCCCCCCC)N. InChi Code: InChI=1S/C24H45NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h10-11,14-15,18-24,26-30H,2-9,12-13,16-17,25H2,1H3/b11-10+,15-14+/t18-,19+,20+,21+,22-,23+,24+/m0/s1. InChi Key: HWRVJNPAUIAOKZ-ONHJFEJBSA-N.