Pseudomonic Acid (lithium salt)

Pseudomonic acid is an antibiotic and bacterial metabolite that has been found in P. fluorescens. It is bacteriostatic against S. aureus (MIC = 0.05 µg/ml) and active against skin wound clinical isolates of methicillin-resistant S. aureus (MRSA, MICs = 1-4 µg/ml). Pseudomonic acid inhibits MRSA and P. aeruginosa biofilm formation in vitro. It inhibits bacterial cell wall isoleucyl-tRNA synthetase, slowing bacterial growth. Topical administration of pseudomonic acid (2% v/v) reduces the number of wound colony forming units (CFUs) in a mouse model of MRSA skin infection.Formal Name: 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]-2-oxiranyl]methyl]-3-methyl-L-talo-non-2-enonic acid, 8-carboxyoctyl ester, monolithium salt. CAS Number: 73346-79-9. Molecular Formula: C26H43O9 . Li. Formula Weight: 506.6. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 223 nm. SMILES: C[C@H](O)[C@H](C)[C@@](O1)([H])[C@@H]1C[C@@H]2[C@H]([C@H]([C@@H](OC2)C/C(C)=C/C(OCCCCCCCCC([O-])=O)=O)O)O.[Li+]. InChi Code: InChI=1S/C26H44O9.Li/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27,/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29),/q,+1/p-1/b16-13+,/t17-,18-,19-,20-,21-,24+,25-,26-,/m0./s1. InChi Key: XFIKMPRBSORKQP-JATHGWPISA-M. Origin: Bacterium/Pseudomonas fluorescens.