Penicillin G, Sodium Salt USP (Benzylpenicillin sodium, Sodium benzylpenicillinate)

Penicillin G is a broad based antibiotic used in mammalian cell culture. Penicillin G blocks the formation of bacterial cell walls, rendering bacteria unable to multiply and spread. The spectrum of activity of Penicillin G includes many aerobic and anaerobic gram-positive organisms. Aerobes susceptible to Penicillin G include most beta-hemolytic streptococci, beta-lactamase-negative staphylococci, Actinomyces species, some Bacillus anthracis, Corynebacterium species, and Erysipelothrix rhusiopathiae. Most species of anaerobes, including Clostridium species, but excluding beta-lactamase-producing Bacteroides species, are also susceptible to Penicillin G. Penicillin G is easily inactivated by beta-lactamases and has little efficacy against organisms that can produce these enzymes. In addition, Penicillin G is ineffective against those bacteria that are resistant by other mechanisms, such as having a relatively impermeable cell wall. Therefore, Penicillin G has little activity against many staphylococci and most gram-negative bacteria. Appearance: White to off white crystalline powder, Purity: 96-102.0%, Potency: 1500-1750u/mg, Identification: Conforms to USP, Specific Rotation (C=0.7): +285 to +310° , pH:, 5.5-7.5, Loss on Drying: <1.0%, Absorbance: 264nm: As reported, 280nm: As reported, 325nm: As reported, Endotoxin: <0.16U/mg, Related Substances: <1.0% , 2-Ethylhexanoic Acid: , <0.5%