Omadacycline

Omadacycline is an aminomethylcycline antibiotic. It is active against tetracycline-susceptible and -resistant strains of S. aureus, E. faecalis, E. faecium, S. pneumoniae, and E. coli, as well as beta-hemolytic streptococci (MICs = =0.06-2 µg/ml). Omadacycline increases survival in mouse models of systemic infection with tetracycline-sensitive and -resistant strains of S. pneumoniae, S. aureus, or E. coli (ED50s = 0.3-3.34 mg/kg). Formulations containing omadacycline have been used in the treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI).Formal Name: 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4S,4aS,5,5aR,6,11,12aS-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide. CAS Number: 389139-89-3. Synonyms: Amadacycline, BAY 73-7388, MK-2764. Molecular Formula: C29H40N4O7. Formula Weight: 556.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: slightly soluble, PBS (pH 7.2): slightly soluble. lambdamax: 253, 350 nm. SMILES: CN(C)[C@H](C(O)=C1C(N)=O)[C@@]2([H])[C@@](C(O)=C(C(C3=C(O)C(CNCC(C)(C)C)=CC(N(C)C)=C3C4)=O)[C@]4([H])C2)(O)C1=O. InChi Code: InChI=1S/C29H40N4O7/c1-28(2,3)12-31-11-14-10-17(32(4)5)15-8-13-9-16-21(33(6)7)24(36)20(27(30)39)26(38)29(16,40)25(37)18(13)23(35)19(15)22(14)34/h10,13,16,21,31,34,36-37,40H,8-9,11-12H2,1-7H3,(H2,30,39)/t13-,16-,21-,29-/m0/s1. InChi Key: JEECQCWWSTZDCK-IQZGDKDPSA-N.