Negamycin (hydrochloride)

Negamycin is an antibiotic originally found in Streptomyces. It is active against various species of bacteria, including E. coli, S. typhosa, and K. pneumoniae, when used at concentrations ranging from 3.12 to 100 µg/ml. Negamycin (250 µM) stabilizes the interaction between tRNA and ribosomes and decreases the rate of mRNA translation. It also restores the auditory brainstem response to sound tones in a dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy (DMD) when administered at a dose of 100 mg/kg.Formal Name: N-((3R,5R)-3,6-diamino-5-hydroxyhexanamido)-N-methylglycine, monohydrochloride. Synonyms: (+) Negamycin. Molecular Formula: C9H20N4O4 . HCl. Formula Weight: 284.7. Purity: >80%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Water: Soluble. SMILES: NC[C@H](O)C[C@@H](N)CC(NN(C)CC(O)=O)=O.Cl. InChi Code: InChI=1S/C9H20N4O4.ClH/c1-13(5-9(16)17)12-8(15)3-6(11)2-7(14)4-10,/h6-7,14H,2-5,10-11H2,1H3,(H,12,15)(H,16,17),1H/t6-,7-,/m1./s1. InChi Key: NEDXOMDIXKPXQU-ZJLYAJKPSA-N. Origin: Bacterium/Streptomyces sp. M890-C2.