NAI-108

Isolated from Actinoallomurus sp. White to off-white powder. Soluble in DMSO, aqueous acetonitrile or ethanol. Antibacterial class I lantibiotic. Brominated variant of NAI-107. Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II (Lipid II), a key intermediate in peptidoglycan biosynthesis. Efficiently interfers with late stages of cell wall biosynthesis leading to accumulation of the soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide (UDP-MurNAc-pentapeptide) in the cytoplasm. Slightly higher activity than NAI-107 against multidrug-resistant Gram-positive pathogens.