Mitomycin C

Mitomycin C (MMC) is an antitumor antibiotic that was discovered as a fermentation product of S. caespitosus. As an alkylating agent, its activity depends on reductive activation either through low pH or DT-diaphorase or NADH cytochrome c reductase. Activated MMC crosslinks double stranded DNA and is widely used as a tool to selectively inhibit DNA synthesis and mutagenensis, to stimulate genetic recombination, chromosome breakage and sister chromatid exchange, and to induce DNA repair. MMC has clinical significance in combination cancer chemotherapy of solid tumors as well as for modulating wound healing after ophthalmological surgeries and in the management of various corneal disorders.Formal Name: 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1aS,2,8S,8aR,8bS-hexahydro-8a-methoxy-5-methyl-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione. CAS Number: 50-07-7. Synonyms: Ametycine, MitoExtra, Mitonco, Mitoplus, MMC, NSC 26980. Molecular Formula: C15H18N4O5. Formula Weight: 334.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.1 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 216, 359 nm. SMILES: NC1=C(C)C(C(N(C[C@H]2[C@@H]3N2)[C@@]3(OC)[C@@H]4COC(N)=O)=C4C1=O)=O. InChi Code: InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1. InChi Key: NWIBSHFKIJFRCO-WUDYKRTCSA-N.