Maduramicin (ammonium salt)

Maduramicin is a polyether ionophore antibiotic that has been found in Nocardia. It selectively binds to potassium, rubidium, sodium, lithium, and cesium ions over divalent cations. Maduramicin is active against Gram-positive bacteria (MICs = 0.9-125 µg/ml) but not Gram-negative bacteria (MICs = >1,000 µg/ml) or fungi (MICs = 250->1,000 µg/ml). It reduces the viability of asexual and gametocyte P. falciparum parasites (EC50s = 1.3 and 14.8 nM, respectively) and reduces P. berghei transmission in a mouse model of malaria when administered at doses of 4 and 8 mg/kg. Maduramicin (5-10 ppm in the diet) reduces the severity of lesions and completely protects chicks against mortality in a model of coccidiosis induced by E. tenella. Formulations containing maduramicin have been used in the treatment of coccidiosis in chickens.Formal Name: maduramicin alpha, monoammonium salt. CAS Number: 84878-61-5. Synonyms: Antibiotic X-14868A, CL 259,971, Maduramycin, Prinicin. Molecular Formula: C47H79O17 . NH4. Formula Weight: 934.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml. SMILES: [H][C@](O1)([C@@]2([H])O[C@@](O)(C)[C@H](C)C[C@@H]2C)C[C@H](O[C@@H]3C[C@H](OC)[C@@H](OC)[C@H](C)O3)[C@]1([H])[C@@](CC4)(C)O[C@@]4([H])[C@@](CC5)(C)O[C@@]65O[C@@]([C@@H](C)[C@]7([H])O[C@@](CC([O-])=O)(O)[C@@H](C)[C@H](OC)[C@H]7OC)([H])[C@H](C)[C@@H](O)C6.[NH4+]. InChi Code: InChI=1S/C47H80O17.H3N/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50,/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50),1H3/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+,/m0./s1. InChi Key: WQGJEAMPBSZCIF-HKSLRPGUSA-N. Origin: Synthetic.