Kendomycin

Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM). It also acts as an endothelin receptor antagonist and has antiosteoporotic activities. Certain effects are thought to be mediated through inhibition of proteasomal degradation of proteins.Formal Name: (13E)-6R,7S,8R,9R,10,11,12S,15,16S,17,18S,19S-dodecahydro-4,7,19-trihydroxy-2,6,8,12,14,16,18-heptamethyl-1,19:5R,9-diepoxybenzocyclooctadecen-3(5H)-one. CAS Number: 183202-73-5. Synonyms: TAN 2162. Molecular Formula: C29H42O6. Formula Weight: 486.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. SMILES: C[C@@H](CC[C@]1([H])[C@H](C)[C@H](O)[C@@H](C)[C@](O1)([H])C2=C(O)C3=O)/C=C(C[C@@H](C)C[C@H](C)[C@@]4(O)C=C2C(O4)=C3C)\C. InChi Code: InChI=1S/C29H42O6/c1-14-8-9-22-18(5)24(30)19(6)28(34-22)23-21-13-29(33,17(4)12-16(3)11-15(2)10-14)35-27(21)20(7)25(31)26(23)32/h10,13-14,16-19,22,24,28,30,32-33H,8-9,11-12H2,1-7H3/b15-10+/t14-,16+,17-,18-,19+,22+,24-,28+,29+/m0/s1. InChi Key: HKLDUJXJTQJSEJ-OLXNOMCWSA-N.