Indolmycin

Indolmycin is an antibiotic isolated from various Streptomyces strains that functions by competitively inhibiting the prokaryotic tryptophanyl-tRNA synthetase (IC50 = 30 µM) without significantly affecting the corresponding eukaryotic synthetase. It exhibits antibacterial activity against mupirocin- and fusidic acid-resistant strains of Staphylococci.Formal Name: 5S-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-4(5H)-oxazolone. CAS Number: 21200-24-8. Synonyms: PA 155A, TAK-083. Molecular Formula: C14H15N3O2. Formula Weight: 257.3. Purity: >95%. Formulation: (Request formulation change), A powder. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(N=C(NC)O1)[C@]1([H])[C@H](C)C2=CNC3=CC=CC=C32. InChi Code: InChI=1S/C14H15N3O2/c1-8(12-13(18)17-14(15-2)19-12)10-7-16-11-6-4-3-5-9(10)11/h3-8,12,16H,1-2H3,(H,15,17,18)/t8-,12+/m1/s1. InChi Key: GNTVWGDQPXCYBV-PELKAZGASA-N. Origin: Bacterium/Streptomyces sp..