Helvolic Acid

Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.Formal Name: (4alpha,6beta,8alpha,9beta,13alpha,14beta,16beta,17Z)-6,16-bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid. CAS Number: 29400-42-8. Synonyms: BRN 3230584, Fumigacin, NSC 319943. Molecular Formula: C33H44O8. Formula Weight: 568.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 229 nm. SMILES: CC(O[C@H]1C[C@]2(C)[C@@]3(C)C([C@@H](OC(C)=O)[C@@]4([H])[C@H](C)C(C=C[C@]4(C)[C@]3([H])CC[C@@]2([H])/C1=C(C(O)=O)\CC/C=C(C)/C)=O)=O)=O. InChi Code: InChI=1S/C33H44O8/c1-17(2)10-9-11-21(30(38)39)26-22-12-13-25-31(6)15-14-23(36)18(3)27(31)28(41-20(5)35)29(37)33(25,8)32(22,7)16-24(26)40-19(4)34/h10,14-15,18,22,24-25,27-28H,9,11-13,16H2,1-8H3,(H,38,39)/b26-21-/t18-,22+,24+,25+,27-,28+,31-,32+,33-/m1. InChi Key: MDFZYGLOIJNNRM-OAJDADRGSA-N.