Finafloxacin (hydrochloride)

Finafloxacin is a fluoroquinolone antibiotic. It is active against S. pneumoniae and P. aeruginosa, as well as methicillin-resistant S. aureus (MRSA) that is sensitive or resistant to fluoroquinolones (MIC90s = 2, 2, 0.125, and 4 mg/L, respectively). Finafloxacin (23.1 mg/kg) improves survival in F. tularensis- or Y. pestis-infected mice in models of tularemia or plague, respectively. Formulations containing finafloxacin have been used in the treatment of acute otitis externa.Formal Name: 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride. CAS Number: 209342-41-6. Synonyms: BAY35-337. Molecular Formula: C20H19FN4O4 . HCl. Formula Weight: 434.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 245, 286, 371 nm. SMILES: FC1=CC2=C(C(C#N)=C1N3C[C@@](NCCO4)([H])[C@]4([H])C3)N(C5CC5)C=C(C(O)=O)C2=O.Cl. InChi Code: InChI=1S/C20H19FN4O4.ClH/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15,/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28),1H/t15-,16-,/m0./s1. InChi Key: CQMSQUOHWYYEKM-MOGJOVFKSA-N.