Clindamycin (hydrochloride hydrate)

Clindamycin is a lincosamide antibiotic. It is active against Gram-positive bacteria, including various strains of S. pneumoniae, S. viridans, S. aureus, and S. epidermidis (MICs = 0.002-0.1, 0.005-0.2, 0.04-1.6, and 0.1-0.2 µg/ml, respectively). Clindamycin is also active against chloroquine-resistant and -sensitive strains of P. falciparum (IC50s = 3.12 and 8.81 nM, respectively). It inhibits bacterial protein synthesis by interacting with the 50S ribosome. Clindamycin increases survival in a mouse model of a secondary S. pneumoniae infection when administered at a dose of 15 mg/kg twice daily for seven days. Formulations containing clindamycin have been used in the treatment of bacterial infections.Formal Name: (2S-trans)-methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octopyranoside, monohydrochloride, monohydrate. CAS Number: 58207-19-5. Molecular Formula: C18H33ClN2O5S . HCl [H2O]. Formula Weight: 479.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 1 mg/ml, Ethanol: slightly, PBS (pH 7.2): 5 mg/ml. SMILES: O=C([C@@H]1C[C@H](CN1C)CCC)N[C@@H]([C@@]2([H])O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C.Cl.O. InChi Code: InChI=1S/C18H33ClN2O5S.ClH.H2O/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4,,/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25),1H,1H2/t9-,10+,11-,12+,13-,14+,15+,16+,18+,,/m0../s1. InChi Key: KWMXKEGEOADCEQ-WNNJHRBUSA-N.