Cefquinome (sulfate)

Cefquinome is a broad-spectrum cephalosporin antibiotic. It is active against clinical isolates of various Gram-positive and Gram-negative bacteria, including Salmonella, E. coli, and methicillin-resistant S. aureus (MRSA, MICs = 0.06-0.5, 0.015-0.5, and 1-16 µg/ml, respectively). Intramammary administration of cefquinome (75 mg/animal) is curative in a bovine model of E. coli-induced mastitis. Formulations containing cefquinome have been used in the treatment of coliform mastitis in veterinary medicine.Formal Name: 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydro-quinolinium, monosulfate. CAS Number: 118443-89-3. Synonyms: HR 111V sulfate. Molecular Formula: C23H25N6O5S2 . HSO4. Formula Weight: 626.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 267 nm. SMILES: O=C(/C(C1=CSC(N)=N1)=N\OC)N[C@H](C2=O)[C@]3([H])N2C(C(O)=O)=C(C[N+]4=C(CCCC5)C5=CC=C4)CS3.O=S([O-])(O)=O. InChi Code: InChI=1S/C23H24N6O5S2.H2O4S/c1-34-27-16(14-11-36-23(24)25-14)19(30)26-17-20(31)29-18(22(32)33)13(10-35-21(17)29)9-28-8-4-6-12-5-2-3-7-15(12)28,1-5(2,3)4/h4,6,8,11,17,21H,2-3,5,7,9-10H2,1H3,(H3-,24,25,26,30,32,33),(H2,1,2,3,4)/b27-16-,/t17-,21-,/m1./s1. InChi Key: KYOHRXSGUROPGY-OFNLCGNNSA-N.