Cefotetan (sodium salt)

Cefotetan is a cephamycin antibiotic that is active against both Gram-positive and Gram-negative bacteria including isolates of E. coli, S. aureus, K. pneumoniae, and P. maltophilia (MICs = 0.03-32 mg/ml). It reduces mortality by 50% in a rabbit model of fecal peritonitis when administered at a dose of 25 mg/kg twice daily. Formulations containing cefotetan have been used in the treatment of various bacterial infections.Formal Name: (6R,7S)-7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt. CAS Number: 74356-00-6. Synonyms: YM-09330. Molecular Formula: C17H15N7O8S4 . 2Na. Formula Weight: 619.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 290 nm. SMILES: O=C(N[C@@]1(OC)[C@](SCC(CSC2=NN=NN2C)=C3C([O-])=O)([H])N3C1=O)C4S/C(S4)=C(C([O-])=O)\C(N)=O.[Na+].[Na+]. InChi Code: InChI=1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28,,/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30),,/q,2*+1/p-2/b12-6-,,/t13?,15-,17+,,/m1../s1. InChi Key: ZQQALMSFFARWPK-GLHLDKNHSA-L.