Cefoselis (sulfate)

Cefoselis is a cephalosporin antibiotic. It is active against clinical isolates of extended-spectrum beta-lactamase-producing E. coli, K. pneumoniae, and P. mirabilis, as well as C. freundii, E. aerogenes, E. cloacae, S. marcescens, and P. vulgaris with susceptibility rates ranging from 56.7 to greater than 94%. Cefoselis is protective against lethality in mouse models of systemic methicillin-susceptible S. aureus (MSSA), low-level methicillin-resistant S. aureus (L-MRSA), high-level methicillin-resistant S. aureus (H-MRSA), S. pneumoniae, E. coli, K. pneumoniae, or P. aeruginosa infection (ED50s = =0.025-1.56 mg/kg). It reduces the number of renal colony forming units (CFUs) in a mouse model of S. epidermidis-induced ascending pyelonephritis when administered at a dose of 50 mg/kg.Formal Name: (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosulfate. CAS Number: 122841-12-7. Synonyms: FK-037. Molecular Formula: C19H22N8O6S2 . H2SO4. Formula Weight: 620.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 1 mg/ml. lambdamax: 261 nm. SMILES: O=S(O)(O)=O.CO/N=C(C1=CSC(N)=N1)\C(N[C@H]2[C@](SCC(CN3N(CCO)C(C=C3)=N)=C4C(O)=O)([H])N4C2=O)=O. InChi Code: InChI=1S/C19H22N8O6S2.H2O4S/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28,1-5(2,3)4/h2-3,8,13,17,20,28H,4-7H2,1H3,(H2,21,22)(H,23,29)(H,31,32),(H2,1,2,3,4)/b20-11?,24-12-,/t13-,17-,/m1./s1. InChi Key: LZOLCSVRFKCSEM-ZQCAECPKSA-N.