CAY10742

CAY10742 is an orally bioavailable oxadiazole antibiotic. It is active against the Gram-positive bacteria S. aureus, S. epidermidis, S. haemolyticus, B. cereus, B. licheniformis, E. faecalis, and E. faecium (MICs = 1-4 µg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistant S. aureus (MRSA) infection.Formal Name: 5-[3-[4-(4-fluorophenoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-indole. CAS Number: 1649473-91-5. Molecular Formula: C22H14FN3O2. Formula Weight: 371.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 11mg/mL, DMF:PBS (pH 7.2) (1:2): 0.3mg/mL, DMSO: 10mg/mL. lambdamax: 262 nm. SMILES: FC(C=C1)=CC=C1OC(C=C2)=CC=C2C3=NOC(C4=CC=C5C(C=CN5)=C4)=N3. InChi Code: InChI=1S/C22H14FN3O2/c23-17-4-8-19(9-5-17)27-18-6-1-14(2-7-18)21-25-22(28-26-21)16-3-10-20-15(13-16)11-12-24-20/h1-13,24H. InChi Key: LJMUZZUGHRTIJT-UHFFFAOYSA-N.