Berninamycin A (Berninamycin, Antibiotic U27810)

Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, members of the MerR proteins that are central regulators in multidrug resistence. Closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1., , DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water