Aerothionin

Aerothionin is a dimeric spiroisoxazoline derived from marine sponges that demonstrates antimycobacterial activity. It is cytotoxic to HeLa cells, inhibiting proliferation with an IC50 value of 29 µM.Formal Name: (5S,5'S,10R,10'R)-N,N'-1,4-butanediylbis[7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide. CAS Number: 28714-26-3. Molecular Formula: C24H26Br4N4O8. Formula Weight: 818.1. Purity: >97%. Formulation: (Request formulation change), A film. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: O=C(NCCCCNC(C1=NO[C@@]2([C@@H](O)C(Br)=C(OC)C(Br)=C2)C1)=O)C3=NO[C@@]4([C@@H](O)C(Br)=C(OC)C(Br)=C4)C3. InChi Code: InChI=1S/C24H26Br4N4O8/c1-37-17-11(25)7-23(19(33)15(17)27)9-13(31-39-23)21(35)29-5-3-4-6-30-22(36)14-10-24(40-32-14)8-12(26)18(38-2)16(28)20(24)34/h7-8,19-20,33-34H,3-6,9-10H2,1-2H3,(H,29,35)(H,30,36)/t19-,20-,23+,24+/m0/s1. InChi Key: BJWQSQOWGBUSFC-UWXQAFAOSA-N. Origin: Animal/Suberea sp..