NY-ESO-1-Specific TCR Lentivirus (Clone c259)

The human NY-ESO-1-specific T Cell Receptor (TCR) lentiviruses (clone c259, also called alpha95:LY) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with a human TCR (clone c259) that specifically recognizes antigen NY-ESO-1 (New York esophageal squamous cell carcinoma 1), and in which the TCR alpha chain and beta chain are linked by P2A. The lentiviruses also transduce a puromycin selection gene.